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Article
January 21, 1956

USE OF CHLORPROMAZINE AND RESERPINE IN THE TREATMENT OF EMOTIONAL DISORDERS

JAMA. 1956;160(3):179-184. doi:10.1001/jama.1956.02960380027008
Abstract

• Patients receiving uninterrupted medication with either chlorpromazine or reserpine constituted a control group for comparison with a group in whom the medication was interrupted by one month of medication with a placebo. Both chlorpromazine and reserpine caused significant behavioral and affective improvement, especially in the manic phase of manic-depressive psychosis, in agitated states, and in schizophrenic reaction. The drugs differed in their side-effects, but they are valuable to the psychiatrist in controlling destructive, disturbed behavior regardless of the underlying etiology.

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