• Patients receiving uninterrupted medication with either chlorpromazine or reserpine constituted a control group for comparison with a group in whom the medication was interrupted by one month of medication with a placebo. Both chlorpromazine and reserpine caused significant behavioral and affective improvement, especially in the manic phase of manic-depressive psychosis, in agitated states, and in schizophrenic reaction. The drugs differed in their side-effects, but they are valuable to the psychiatrist in controlling destructive, disturbed behavior regardless of the underlying etiology.
Zeller WW, Graffagnino PN, Cullen CF, Rietman HJ. USE OF CHLORPROMAZINE AND RESERPINE IN THE TREATMENT OF EMOTIONAL DISORDERS. JAMA. 1956;160(3):179–184. doi:10.1001/jama.1956.02960380027008
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