• Cystitis in 86 female patients was treated by administering orally a combination of two drugs, sulfamethylthiadiazole and 2,6-diamino-3-phenylazopyridine hydrochloride. These have, respectively, an antibacterial and an anesthetic effect. The dysuria and frequency were generally diminished within 24 hours; cures were achieved in 48 cases and improvement in 22. Escherichia coli was the organism most frequently found.
Chemotherapy is likely to be inadequate if the causative lesion is not located, but the combined action of these two drugs was highly satisfactory because it relieved pain and discomfort. No toxic effects were noted in 117 patients treated therewith.
Toland WJ, Schwartz JW. COMBINATION TREATMENT OF URINARY TRACT INFECTION. JAMA. 1956;160(7):542–543. doi:10.1001/jama.1956.02960420022006
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