• Triple-drug therapy for renal tuberculosis consisted of 1 gm. of streptomycin twice weekly, 100 mg. of isoniazid thrice daily, and 5 gm. of sodium aminosalicylic acid thrice daily, all given simultaneously and without interruption for a year. This treatment was administered to 20 patients who had renal lesions of the cavitary type and whose urine contained Mycobacterium tuberculosis. They were reexamined a year after completing the course. No relapses had occurred. The urine had remained negative, and a kidney removed from one patient who died of cardiac disease at this time showed a scar without histological evidence of tuberculosis.
Comparison with two other series of patients who had renal tuberculosis of equal severity showed that the three drugs together were more effective than streptomycin plus isoniazid and far more effective than streptomycin alone.
Lattimer JK, Wechsler H, Spirito AL, Whittle GT. TREATMENT OF RENAL TUBERCULOSIS WITH TRIPLE-DRUG THERAPYUSE OF A COMBINATION OF STREPTOMYCIN, ISONIAZID, AND SODIUM AMINOSALICYLIC ACID. JAMA. 1956;160(7):544–546. doi:10.1001/jama.1956.02960420024007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: