• Zoxazolamine was administered to patients with spasticity and other forms of uncontrolled muscular activity ascribed to disease in either the spinal cord or the brain. The expected relaxing effect was best seen in patients with lesions in the spinal cord, especially multiple sclerosis. Of 18 patients in the spinal group, 14 showed undoubted reduction of spasticity. This was especially convincing in a paraplegic patient whose previously uncontrolled mass flexion spasms were markedly reduced.
The effects on patients with diseases affecting the brain, especially paralysis agitans and hemiplegia, were less predictable. In some instances the drug made the symptoms worse. In one case of encephalomyelitis surgery had been contemplated to relieve intolerable spasms of the adductors of the thigh, but the operation became unnecessary when the drug gave relief.
Further investigation of the effects of zoxazolamine will be necessary in order to explain its action and define its range of usefulness.
Rodriguez-Gomez M, Valdes-Rodriguez A, Drew AL. EFFECT OF ZOXAZOLAMINE (FLEXIN) IN TREATMENT OF SPASTICITY: PRELIMINARY REPORT. JAMA. 1956;160(9):752–754. doi:10.1001/jama.1956.02960440024007
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