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May 7, 1949

The Therapeutic Value of Penicillin: A Study of 10,000 Cases

JAMA. 1949;140(1):131. doi:10.1001/jama.1949.02900360133026

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This book is of special historic interest, since it represents the report of the first extensive nationwide study to determine the clinical use of a chemotherapeutic agent. Before penicillin became generally available for use in this country, its distribution and use were controlled by the Committee on Therapeutics and Other Agents of the National Research Council. During the period between 1942 and 1945, detailed reports of the use of penicillin in more than 10,000 patients were submitted to this committee. The reports were arranged according to etiologic and anatomic diagnoses and analyzed statistically, and the findings were commented on by the authors.

The conclusions reported in this book are only very generally applicable to the administration of penicillin at the present time. The doses and methods of the administration of penicillin have changed greatly, even in the short period that has elapsed since this study was undertaken. In the early

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