• An elderly man underwent a transurethral prostatectomy necessitated by carcinoma of the prostate. A year later he returned to the hospital with widespread metastases, pain in the lower extremities, and severe anemia. Ecchymoses present at admission were followed by frank gingival hemorrhages.
The clotting time of his blood exceeded 30 minutes, and efforts to determine the exact nature of this hemorrhagic diathesis were made by determining the fibrinogen content, semenolytic activity, caseinolytic activity, and other properties of the blood. No simple explanation was found.
The patient's fibrinogen level was twice raised temporarily by intravenous administration of about 5 gm. of human fibrinogen in 1% solution, but it was not affected by diethylstilbestrol diphosphate intravenously, by ethinyl estradiol, by cortisone, or by antihemophilic plasma.
At autopsy, neither the liver nor the spleen showed abnormalities, but the bone marrow generally was replaced by hard, gray homogeneous matter.
Prout GR, Siegel M, Cliffton EE, Whitmore WF. HEMORRHAGIC DIATHESIS IN PATIENTS WITH CARCINOMA OF PROSTATE. JAMA. 1956;160(10):840–846. doi:10.1001/jama.1956.02960450022006
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