• Penicillin V resists gastric digestion and is effective when given by mouth. Satisfactory concentrations in the serum were found during treatment with 200,000 units given every four hours and were adequate for minor infections with susceptible organisms. In the most severe infections, such as bacterial endocarditis, the dosage can be raised to one million units.
The action of penicillin V was studied in 18 patients. Four illustrative case histories are given in some detail. The most frequent untoward reaction was gastrointestinal, and one patient had a rather severe aphthous stomatitis, but the more severe allergic reactions were not encountered.
Martin WJ, Nichols DR, Heilman FR. OBSERVATIONS ON CLINICAL USE OF PHENOXYMETHYL PENICILLIN (PENICILLIN V). JAMA. 1956;160(11):928–931. doi:10.1001/jama.1956.02960460006002
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