• Nine patients with pemphigus vulgaris were followed through periods of remission and exacerbation. All but one were at one time moribund and would almost certainly have died if corticotropin had not been available to them. All experienced remissions during which no corticotropin was needed, and all at one time or another had exacerbations that required greatly increased doses of corticotropin for control.
Corticotropin never failed to suppress the blister formation. Side-effects were minimal. Except during the remissions, which are infrequent, the dosage needed has been remarkably constant, so that the therapy can be continued on an outpatient basis for indefinite periods of time.
Stoughton RB. LONG-TERM MANAGEMENT OF PEMPHIGUS VULGARIS WITH CORTICOTROPIN (ACTH). JAMA. 1956;160(12):1011–1014. doi:10.1001/jama.1956.02960470007002
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: