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April 7, 1956


JAMA. 1956;160(14):1233. doi:10.1001/jama.1956.02960490047013

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The parenteral administration of medicaments has become universally popular since the hypodermic syringe was introduced in medical practice more than a century ago. While hypodermic injection provides an effective means for therapy that cannot be given orally, it is a procedure that has certain limitations due to the narrow tolerance of the tissues.

Drugs for parenteral use are kept in containers in a sterile condition or are sterilized just before they are used, depending partly on the nature of the drug and partly on available facilities. In sterile form they are contained in single-dose glass ampuls or in multiple-dose vials with a rubber closure. The most convenient form is a sterile solution of the drug in a form ready for withdrawal into the syringe, but, since useful drugs vary in solubility, present-day preparations vary from the most desirable isotonic aqueous solutions to various extremes of aqueous solutions, suspensions, and solutions

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