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April 21, 1956


JAMA. 1956;160(16):1431. doi:10.1001/jama.1956.02960510057024

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To the Editor:—  Although I have stated previously that the new tranquilizing drug meprobamate is not habit forming (New Tranquilizing Drugs, Northwest Med.54:1098, 1955), further clinical experience has led me to believe that this is not alwaysalways the case. Many patients become quite dependent on meprobamate and find it difficult to get along without it. In this sense, it is evident that this drug is sometimes habit forming. There is reason to believe that meprobamate may even have at least mild habituation properties in a few patients. Addiction to a drug is characterized by (1) psychic craving based on euphoric effects, (2) building up of tolerance requiring increasingly large doses to produce the same reaction, and (3) withdrawal symptoms when medication is suddenly stopped. Meprobamate is not habit forming in respect to any increase in tolerance. On the contrary, one of the major advantages of this drug has

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