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Article
July 9, 1949

DESOXYCORTICOSTERONE ACETATE NOT A SUBSTITUTE FOR COMPOUND E IN ARTHRITIS

JAMA. 1949;140(10):909. doi:10.1001/jama.1949.02900450059021

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Abstract

To the Editor:—  In a recent issue of The Journal (April 30, p. 1274) the work of the Mayo group dealing with the use of Kendall's compound E in the treatment of rheumatoid arthritis was cited and discussed. Shortly thereafter I learned of an instance in which desoxycorticosterone acetate was being used for the same purpose.In a check on four leading pharmacists, one reported "many" purchases by physicians for use in cases of rheumatoid arthritis. From our present knowledge of adrenal physiology, especially the work of Selye, the administration of desoxycorticosterone acetate in rheumatoid arthritis is to be condemned.I feel that this matter should be stressed to prevent the possible widespread, improper use of desoxycorticosterone acetate.

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