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August 13, 1949


Author Affiliations

Ann Arbor, Mich.
From the Department of Pathology, University of Michigan.

JAMA. 1949;140(15):1201-1205. doi:10.1001/jama.1949.02900500009002

Renal insufficiency as a complication of pregnancy, and particularly of abortion, has long attracted serious consideration. At necropsy the organs of fatal cases in this group are found with morphologic features in common; and there is a constant relationship between the clinical syndrome and these structural changes. Comparison of this relationship with that resulting from other causes has made possible a more complete explanation of postabortal oliguria.

Bywaters and Beall1 in 1941 activated interest in the clinical-pathologic picture which followed crush injuries sustained in the London air raids. The triad of crushing injury, subsequent renal failure and histopathologic alterations in the kidneys focused the attention of clinicians and pathologists on this disease entity, which they called the crush syndrome. The onset of symptoms 2 follows in the wake of crushing trauma or other precipitating factors with or without evidence of shock. Nausea, vomiting, malaise and abdominal pain are usually

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