The synthesis of a physiologically active iodine-containing protein with a specific calorigenic effect has always been assumed to be limited to the thyroid gland. The localization of almost all the iodine of the body in the thyroid and the metabolic influence of the gland have served to emphasize the relationship of the iodinecontaining compounds of the thyroid to the regulation of energy metabolism. The synthesis and the degradation of thyroglobulin have been considered to be fundamental reactions under the control of the thyroid. Now come reports of the preparation of proteins of extrathyroidal origin which possess metabolic effects formerly considered to be restricted to the thyroid gland and to products derived from it. Perhaps this work will prove of fundamental importance in providing inexpensive and ready sources of thyroid-like hormone for therapeutic use. The earlier reports of Abelin and his colleagues1 presented evidence that iodized proteins, prepared in the
PHYSIOLOGICALLY ACTIVE IODIZED PROTEINS. JAMA. 1940;115(1):46–47. doi:10.1001/jama.1940.02810270048011
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