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July 13, 1940

SULFATHIAZOLE: TWO CASES OF SEPTICEMIA WITH RECOVERY

JAMA. 1940;115(2):118-120. doi:10.1001/jama.1940.72810280001009
Abstract

The sulfonamide group of drugs has opened up tremendous potentialities in the field of chemotherapeusis and many new avenues for the use of such drugs undoubtedly will be opened.

The limitations of sulfanilamide have been realized and it has become necessary to explore the field further to find synthesized derivatives of this drug which would act where the parent drug has failed, such as in instances of Staphylococcus aureus, Streptococcus faecalis and other resistant organisms. The introduction of sulfapyridine soon followed which seemed to offer potentialities that sulfanilamide did not possess. However, it exhibited serious side effects. Antopol1 recently reported that 40 per cent of a group of patients receiving sulfapyridine showed hematuria. Pepper and his associates found this complication in twenty-seven of 381 patients taking sulfapyridine. The formation of urinary calculi has also been reported in many instances. Nausea and vomiting not infrequently interfere with the continued administration

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