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July 13, 1940

CONFERENCES ON THERAPY: THE TREATMENT OF BLOOD DISORDERS

JAMA. 1940;115(2):126-131. doi:10.1001/jama.1940.72810280009010
Abstract

VII. LEUKEMIA, AGRANULOCYTOSIS AND NEUTROPENIA

Dr. Jacob Furth:  Leukemia and agranulocytosis or neutropenia are two fundamentally different diseases, although the terminology would suggest that one is merely a depression, the other a stimulation, of leukopoietic activity.Agranulocytosis or a milder form of it, neutropenia, can be produced by a variety of agents, and the process is reversible; that is, when the causative agent is removed complete restitution may occur. Leukemia, on the contrary, is a neoplastic disease of leukopoietic tissues, and removal of the causative agent after establishment of a neoplasm will no longer influence the course of the disease. This fundamental concept emphasizing the difference between these two types of disturbance is essential to the understanding of the established treatment of these diseases and to the evaluation of the new procedures that are proposed periodically.In agranulocytosis, necropsy reveals either a hypoplasia of the granulocytic elements of the bone

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