Acute pulmonary edema in mitral stenosis is not infrequent and may be precipitated by a number of factors. Retention of fluid during the menses is well known and may, among other causes, be due to overactivity of the antidiuretic hormone of the posterior lobe of the pituitary gland. In the vast majority of cases there are few resultant phenomena except an increase in body weight. In the case to be reported, however, advanced mitral stenosis was associated with a marked decrease in cardiac reserve, and serious pulmonary symptoms occurred in each of seventeen successive menstrual periods. Blood studies strongly suggested overactivity of the posterior lobe of the pituitary gland, and the subsequent relief afforded by irradiation of the pituitary gland supports this hypothesis. As far as we are able to determine, no case of a similar nature has been reported in the literature.
REPORT OF CASE
Mrs. B. G., aged
Edeiken J, Griffith JQ. CYCLIC PULMONARY EDEMA AT MENSES IN MITRAL STENOSISRELIEF FOLLOWING IRRADIATION OF PITUITARY GLAND. JAMA. 1940;115(4):287–289. doi:10.1001/jama.1940.72810300001007
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