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August 10, 1940

RECURRENT LYMPHOCYTIC CHORIOMENINGITIS TREATED WITH SULFANILAMIDE: ISOLATION OF VIRUS

JAMA. 1940;115(6):436-440. doi:10.1001/jama.1940.02810320016006
Abstract

Lymphocytic choriomeningitis has been recognized as a distinct clinical entity for almost a half century. Wallgren1 reviewed cases through 1924 and referred to this disease as "acute aseptic meningitis." In 1934 Abramson2 reviewed cases up to that time. Toomey3 reported seventy cases in 1936. Dummer. Lyon and Stevenson4 reported twenty-two cases in 1937. There have also been reports by Gibbens,5 Gordon and Abrahams,6 Viets and Watts,7 Ashton,8 Mollaret and Kreis,9 Baird and Rivers,10 Rodier,11 Rankin,12 and Ferru.13 All these reports emphasize the usual features that distinguish this entity. These are the benign course, the symptoms and signs of meningeal irritation, the spinal fluid features of pleocytosis, elevated protein content, and the absence of a bacterial agent. Only in the last five years has the virus nature of this disease been demonstrated by Armstrong and Lillie.14

Matturri-Matrai

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