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August 10, 1940


JAMA. 1940;115(6):454-460. doi:10.1001/jama.1940.72810320010011

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I. GENERAL TREATMENT  Dr. Eugene F. Du Bois: The management of the ordinary, uncomplicated case of diabetes is not difficult these days; the management of emergencies will always remain difficult. Dr. Tolstoi will take up the clinical aspects.Dr. Edward Tolstoi: As the result of recent experiments performed in collaboration with Dr. Weber and Mr. Toscani, we have been led to adopt a somewhat less orthodox point of view in the treatment of the diabetic patient. We found that our experimental subjects were free from the symptoms of diabetes in spite of glycosuria when they were receiving a diet of 75 Gm. of protein, 60 Gm. of fat and 200 Gm. of carbohydrate, and protamine zinc insulin in daily doses of 50 units. Two rather unusual patients whom we observed in the metabolism ward for periods of fifty to sixty days maintained their weight. I want to emphasize this point.

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