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August 17, 1940

The Content of Cells and Proteins in the Normal Cerebro-Spinal Fluid: The Diagnostic Importance of Demonstrating Small Pathological Changes in the Cells and Proteins; The Technique of the Investigation

JAMA. 1940;115(7):559. doi:10.1001/jama.1940.02810330065035

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The author has in this small monograph given a comprehensive and detailed discussion on the subject of the content of cells and proteins in normal and pathologic spinal fluids. He states, "The examination of the cerebrospinal fluid is the most important clinical laboratory examination in neurology and psychiatry. Gradually such an examination has, indeed, come to play a considerable role in the diagnosis of doubtful diseases in internal medicine and pediatry." Between the blood and the cerebrospinal fluid there is a barrier which does not allow protein or other substances of a colloidal nature to pass, while substances of a different nature (electrolytes, dextrose, uric acid, creatinine, nonprotein nitrogen) found in the blood are able to pass into the cerebrospinal fluid, where they can be demonstrated in a quotient which, for some substances (sodium chloride and magnesium) is greater than that in which they occur in the blood. The examination

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