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August 24, 1940


JAMA. 1940;115(8):616-617. doi:10.1001/jama.1940.02810340044012

The role assumed by the proteins of the plasma in physicochemical relationships and in immunologic phenomena of the blood has brought to these constituents more attention than has been given most of the other proteins of the body. Yet the vast amount of experimental work has not provided a clear picture of their formation and fate in the organism. Research work of the past few years has greatly elucidated some aspects of the problem and has afforded at least a working hypothesis with respect to other more obscure phases of the subject. A recent review by Madden and Whipple1 clearly reflects the present status of our knowledge bearing on the source, production and utilization of plasma proteins.

Although there is evidence that the albumin, globulin and fibrinogen factors of plasma are not as sharply defined as was once supposed (indeed, it seems probable that they all form part of