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December 16, 1950

MILK-BORNE VIRUCIDE

JAMA. 1950;144(16):1379. doi:10.1001/jama.1950.02920160053016
Abstract

Experimental evidence suggesting a milk-borne immunity against certain virus diseases was recently reported by Ratner,1 Culbertson,2 Curley3 and others. Using murine poliomyelitis virus, Knox4 of the Department of Bacteriology, Columbia University, confirms their evidence.

At various stages of gestation, 100 pregnant mice were inoculated orally with the murine virus. Eighteen viable litters were born to these inoculated mothers. Half the litter were reared by their own mothers, while others were reared by foster mothers, some of which were normal. Six additional litters were obtained from mothers not infected till after parturition, six litters from mothers of known immunity and four litters from normal mothers. Between the time of weaning and 44 days of age the young were tested for immunity by intranasal instillation of a 1: 100 dilution of the murine virus. Older littermates and adults were tested by intraperitoneal inoculation with five times this dose.

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