One hundred and thirteen cases of epidemic cerebrospinal meningitis, representing for the greater part a small epidemic of the disease in Rhode Island, have been admitted to the Charles V. Chapin Hospital since February 1935. The epidemic gave us an opportunity to study the method of treatment of the "genus epidemicus" type of the disease and also to determine the relative therapeutic value of the antimeningococcus serum, the meningococcus antitoxin of Ferry and sulfanilamide.
A routine method of treatment, similar to the one which had been used successfully at the Herman Kiefer Hospital by Gordon1 during the 1927 to 1931 epidemic in Detroit, was adopted at the beginning of the epidemic when severe and fulminating cases were encountered. This consisted of alternate lumbar and cisternal injections of antimeningococcus serum at intervals of twelve hours during the first thirty-six or forty-eight hours. After this period treatment was administered
GREGORY KK, WEST EJ, STEVENS RE. EPIDEMIC CEREBROSPINAL MENINGITIS (MENINGOCOCCIC): THE TREATMENT OF 113 PATIENTS WITH ANTIMENINGOCOCCUS SERUM, MENINGOCOCCUS ANTITOXIN AND SULFANILAMIDE. JAMA. 1940;115(13):1091–1095. doi:10.1001/jama.1940.02810390031007
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