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The authors describe their extended experience with neutralization tests in experimental poliomyelitis, which in large part consisted in 440 tests with one pool of virus and one pool of human convalescent serums. On the average, the outcome of one test out of six was irregular according to Aycock's analysis of the data, while one test out of four was irregular as judged by the criteria of Schaeffer and Muckenfuss. Thus they regard the present neutralization test as not practical for quantitative purposes and they consider that all attempts to define a minimal infective dose of virus have been unsuccessful. They reason that general epidemiologic principles but not specific immunologic problems have been elucidated by the test. They accept the widespread distribution of humoral neutralizing substances in man and a general immunologic relationship between all strains of poliomyelitic virus. They regard as unsettled the existence of specific immunologic differences among strains
Experimental Poliomyelitis. I: A Critical Review of the Literature with Special Reference to the Use of the Neutralization Test in Immunological Studies. II: The Neutralization Test. A Study of Some Factors Involved in the Neutralizing Action of Immune Serum Against Poliomyelitis Virus. JAMA. 1940;115(14):1221. doi:10.1001/jama.1940.02810400073029
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