A marked difference of opinion exists as to the relationship between microscopic structure and radiosensitivity. This fact complicates the management of many forms of cancer, especially those in which a decision between surgery and irradiation has to be made. My purpose in this communication is to discuss the clinical and pathologic factors related to radiosensitivity of cancer of the larynx, with special emphasis on the value of biopsy in estimating the prognosis and guiding the treatment. This communication is based on a study of approximately 300 cases of cancer of the larynx observed during the last ten years.
Before the advent of irradiation in the treatment of cancer of the larynx, surgeons recognized a relation between their surgical results and the histologic structure of the lesions. This clinical experience and Broders'1 microscopic studies in the grading of cancer led to the view that in general the highly differentiated forms
CUTLER M. CANCER OF THE LARYNX: RELATION BETWEEN GROSS ANATOMY, MICROSCOPIC STRUCTURE AND RADIOSENSITIVITY. JAMA. 1940;115(16):1339–1345. doi:10.1001/jama.1940.02810420025007
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