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October 19, 1940

FURTHER EXPERIENCE WITH DIVINYL ETHER (VINETHENE) ANESTHESIA: REPORT OF 2,050 ADMINISTRATIONS

JAMA. 1940;115(16):1353-1357. doi:10.1001/jama.1940.02810420039010
Abstract

Since the introduction in 1930 of divinyl ether as an anesthetic agent by Leake and Chen1 and the preparation of the pure drug by Ruigh and Major,2 there have been numerous reports in the literature dating from the study by Knoefel and his co-workers3 as to the chemical and pharmacologic properties of this substance. The clinical reports dealing with divinyl ether have appeared more frequently from Canadian, English and German authors. Since first used on human beings (themselves) by Gelfan and Bell,4 the larger series of cases in this country have been reported, among others, by Goldschmidt, Ravdin, Lucke, Muller, Johnston and Ruigh,5 Bourne and Sparling,6 Marvin,7 Beach,8 Ravdin and his co-workers9 and Feldman and Cartin.10 In a previous communication from this institution 335 administrations were reported. Since vinethene has, in our experience, become increasingly popular, a report is being

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