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The author defines the Carolina Low Country as the coastal area extending from peninsular Florida to Cape Hatteras. As a whole this area is not particularly fertile and is poor in mineral wealth. It is in the limited areas suitable for agriculture that malaria is prevalent today and was so virulent in former times. Continuous occupation by people of European stock nowhere dates further back than 1670, when the English settled at Ashley River near the present site of Charleston.
The monograph is divided into seven chapters. The first is introductory and considers the natural history of the malarial parasite and the relation of malaria to colonization in general, Chapters 2 and 3 are devoted to the earlier colonies which failed but which have valuable implications in relation to malaria and the Ashley River settlement. After careful consideration of the various attempts of Ponce de Leon, de Ayllon, de Luna,
Malaria and Colonization in the Carolina Low Country 1526-1696. JAMA. 1940;115(19):1659–1660. doi:10.1001/jama.1940.02810450073033
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