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November 9, 1940

Sulfanilamide, Sulfapyridine and Allied Compounds in Infections

JAMA. 1940;115(19):1660-1661. doi:10.1001/jama.1940.02810450074039

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In the foreword of this book it is stated that the physician needs a book to turn to to find authoritative statements about the therapeutic utility of the sulfonamides which will aid him as a guide in the use of these preparations. This purpose, unfortunately, is not satisfactorily accomplished. A brief introductory section on the pharmacology of sulfanilamide is not well organized, is quite superficial and devotes a fourth of its content to the relatively unimportant question of the excretion of sulfanilamide in the breast milk of lactating women. The paragraphs on methods of administration and dosage are unnecessarily cumbersome and confusing. The stated indications for the use of large, moderate and small doses would in practice need to be modified frequently and sometimes are contradicted elsewhere in the text. For example, puerperal sepsis is included among the conditions requiring only moderate doses, while in a later paragraph dealing with the treatment of this condition it is suggested that the best results may be obtained by maintaining steadily a blood concentration of from 10 to 15 mg. per hundred cubic centimeters. Similarly the section dealing with infections in which sulfanilamide is effective often suffers because of apparent contradictions ; e. g., in discussing the treatment of infections of the urinary tract the author speaks of "the probability that the concentration

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