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November 23, 1940

NEUROGENIC FACTORS IN THE PRODUCTION OF ACUTE GASTRIC ULCER

Author Affiliations

PHILADELPHIA

From the Divisions of Medicine and Neuropathology, Philadelphia General Hospital.

JAMA. 1940;115(21):1771-1773. doi:10.1001/jama.1940.02810470015004
Abstract

Study of fifteen cases of acute gastric ulceration associated with primary intracerebral disease shows no essential pathologic difference between these lesions and the acute gastric ulcer found in the absence of such disease. That the mucosal lesion is the result of an acute phase of gastric circulatory deficiency of a prolonged type is suggested by the presence of chronic degenerative changes in the deeper layers of the stomach wall. Moreover, similar degenerative changes dependent on chronic stasis in the circulatory beds found in other viscera in these cases demonstrate that the so-called "neurogenic" ulcer is not a primary, isolated phenomenon but a focal manifestation of subclinical generalized circulatory insufficiency.

The absence of organic cardiovascular disease in this series, with a mean age of 34 years, permits the assumption that the generalized peripheral circulatory disturbances noted in the viscera mentioned are primarily related to an intracerebral condition. The nature of the

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