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December 23, 1950

The 1949 Year Book of Endocrinology, Metabolism and Nutrition (December 1948 - January 1949). Endocrinology

JAMA. 1950;144(17):1527. doi:10.1001/jama.1950.02920170107037

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This is an attempt to abstract the important literature of the year on endocrinology, metabolism and nutrition, with editorial comment on the findings. In reviewing the editor's comments on pituitary adrenocorticotropic hormone (ACTH) and cortisone, it is interesting to note that an excessive secretion of potassium is reported as producing dangerously low levels of potassium concentration in body fluids. Also, the categorical statement is made that patients treated with these agents have shown all manifestations of Cushing's syndrome. To date, the thin skin, the ecchymoses and polycythemia of Cushing's syndrome have not been reported following pituitary adrenocorticotropic hormone or cortisone therapy. Whether these additional observations will be encountered following administration of these agents over a longer period remains to be seen. In discussing pulmonary tuberculosis, the statement is made that "... production of tubercle bacilli appears not to be affected, and if the ACTH administration is discontinued, a severe relapse occurs."

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