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December 14, 1940


Author Affiliations


From the Department of Biochemistry, McGill University.

JAMA. 1940;115(24):2073-2079. doi:10.1001/jama.1940.72810500005011

THE CORTICOTROPIC FACTOR  It is to be noted that the word "corticotropin" (or "corticotrophin") is now being widely used as a descriptive term for the principle in the anterior lobe of the pituitary gland hitherto commonly spoken of as the adrenotropic factor. This is in line with the general recommendations of the Third International Conference on the Standardization of Hormones.1

Physiologic Significance of Corticotropin.—  There is now a mass of evidence that the maintenance of the cortex of the adrenal gland, in the morphologic as well as the functional sense, is dependent on the secretory activity of the normal anterior lobe of the pituitary. The atrophic adrenals of the completely hypophysectomized animal are not entirely functionless, however, since removal of them from rats hypophysectomized some weeks previously is not tolerated, and death ensues quickly. The function of the corticotropic factor is therefore to maintain the normal structure and function