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December 14, 1940

Allergiya i desensibilizatsiya

JAMA. 1940;115(24):2108. doi:10.1001/jama.1940.02810500076038

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This small volume, published by the Ukrainian Institute of Experimental Medicine, contains brief reports on experimental and clinical studies in allergy and desensitization by Prof. D. E. Alpern and his co-workers. Alpern makes a distinction between specific and nonspecific desensitization. The first consists in creating within the organism a resistance to the antigen by immunobiologic action in the presence of antibodies. By nonspecific desensitization is meant the reduction of the exaggerated reactivity by means other than immunobiologic, namely, through the intervention of the regulatory systems of the organism, its metabolism and so on. There are chapters dealing with animal experiments and clinical trial of histamine, of ultrashort waves and of intermedin. Alpern claims to have obtained this hormone containing extract of the pars intermedia of the hypophysis long before Zondek (1932) described intermedin containing the melanoforming hormone. He describes his method of obtaining the hormone from the hypophysis of small

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