The role of the anterior lobe of the pituitary in intermediary metabolism, especially in carbohydrate metabolism, has been reviewed by Houssay,1 Russell,2 Long,3 Van Dyke,4 Young,5 Thomson and Collip6 and others in recent years, in greater detail and with fuller bibliography than is possible in these pages. The subject is one of the greatest difficulty and complexity, since it is seldom possible to tell how widely the repercussions of any experimental interference may spread through the endocrine system. Great variations in behavior between species and between individuals in any one species are the rule rather than the exception. None of the anterior pituitary principles has yet been obtained in a state of indubitable purity, and any extract of the gland may or may not, depending on the source and the method of preparation, contain not only the thyrotropic and the corticotropic (adrenotropic) hormone (which
THOMSON DL. THE ANTERIOR LOBE OF THE HYPOPHYSIS IN INTERMEDIARY METABOLISM. JAMA. 1940;115(25):2169–2174. doi:10.1001/jama.1940.72810510003012
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