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January 27, 1951


Author Affiliations

Providence, R. I.

JAMA. 1951;145(4):230-231. doi:10.1001/jama.1951.72920220003008b

The association of a tonic pupil and the absence of tendon reflexes was first described independently by Saenger1 and Strasburger2 in 1902. However, it was not until Adie's3 clear delineation of the syndrome 30 years later that it received the serious consideration it deserved. He described the disorder as (1) the complete form—typical tonic pupil and absence of reflexes—and (2) the incomplete forms—(a) tonic pupil alone, (b) atypical phases of the tonic pupil alone, (c) atypical phases of the tonic pupil with absent reflexes and (d) absent reflexes alone.

Numerous reports concerning the syndrome which now bears Adie's name have since appeared, but these have been predominantly in journals devoted to ophthalmology and neurology. The recent observation of a misdiagnosed case of Adie's syndrome has suggested the need for focusing of general attention on this benign entity which has so frequently been erroneously interpreted as a