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February 10, 1951


Author Affiliations

Department of Biochemistry Marquette University School of Medicine, Milwaukee.

JAMA. 1951;145(6):427. doi:10.1001/jama.1951.02920240063024

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To the Editor:—  The problem of hemorrhage caused by bishydroxycoumarin (dicumarol®) which was discussed editorially in The Journal Dec. 23, 1950 (page 1466) deserves serious consideration. It involves more than "the vagaries of the Quick test of prothrombin time." If this test is carried out as I described in The Journal (110:1658 [May 14] 1938), with the correction of a typographical error (111:1775, [Nov. 5] 1938), it will be found that the vagaries are conspicuously absent. Much of the trouble can be attributed to the indiscriminate flood of modifications of the original test and to the reckless introductions of various types of thromboplastin. The thromboplastic reagent that I developed was the result of years of meticulous study and testing. In spite of its commercial possibilities, it was made available without patent attachments. It was described so explicitly that any technician who is capable of following cook book directions

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