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March 10, 1951

Pharmacological Basis of Penicillin Therapy

JAMA. 1951;145(10):771. doi:10.1001/jama.1951.02920280083037

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In this book, emphasis has been placed on the metabolism of penicillin with relatively brief mention of the bacteriologic aspects of penicillin therapy. Over 40 per cent of the volume is devoted to considerations of carinamide and benemid as adjuncts to penicillin therapy. The author is well qualified in this field, being the director of pharmacological research of Sharp and Dohme. The first part of the volume is devoted to a comprehensive review of the literature covering such subjects as the chemistry of penicillin; the factors influencing its absorption from the gastrointestinal tract, with an evaluation of antacid and enteric coated preparations; absorption from other routes of administration; blood and tissue levels, and the characteristics of excretion. An excellent feature is the thorough discussion of the relative merits of short-sustained high and of long-sustained low penicillin blood levels.

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