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March 17, 1951

STAPHYLOCOCCUS AUREUS BACTEREMIA: REPORT OF A CASE WITH CURE BY COMBINED ANTIBIOTIC THERAPY AND SURGICAL ERADICATION OF AN UNUSUAL FOCUS OF INFECTION

Author Affiliations

New York

From the Medical and Gastric services of the Memorial Hospital for Cancer and Allied Diseases.

JAMA. 1951;145(11):819-821. doi:10.1001/jama.1951.72920290009008d
Abstract

Staphylococcic bacteremia, despite the advent of many new antibiotics, remains a disease which carries a most serious prognosis. Anderson and Keefer1 in 1944 estimated that the mortality rate in staphylococcic bacteremia was lowered from 85 to 20 per cent by penicillin. Multiple abscesses, unrecognized or inaccessible abscesses, endocarditis and a disease caused, all too frequently, by penicillin-resistant organisms are the factors which tend to keep the mortality rate high. In the treatment of staphylococcic bacteremia therefore, it is most important to follow the principles set down by Anderson and Keefer: (1) a heavy dosage schedule of antibiotics early in the course of the disease; (2) continuation of therapy until the disease is eradicated, and (3) evacuation of localized areas of pus. The present case is reported because of the successful treatment of staphylococcic bacteremia by large doses of antibiotics in combination and removal of an unusual focus of infection.

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