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March 31, 1951

Biological Standardization

JAMA. 1951;145(13):1020. doi:10.1001/jama.1951.02920310076037

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This is an excellent handbook for the student of pharmacology that develops historically the necessity for biologic standardization of various drugs, the test methods that may be used and the methods of statistical analysis of the results observed. Despite the brevity of the text, the information contained is fairly complete and may be supplemented by the plentiful bibliographic references. Various hormones and digitalis preparations, vitamin D, curare-like compounds, local anesthetics and other drugs are considered in some detail. The section on statistical analysis is skilfully developed and attempts to give the background for the statistical formulas necessary for the analysis of biologic experimentation. The author emphasizes that proper design of experimentation often requires consultation with a statistician during the stage of preliminary planning rather than after data have been accumulated.

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