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New concepts of the physiology and pathology of the bilirubin metabolism are presented in this monograph, which is dedicated to the memory of Hans Fischer, one of the pioneers in this complex field. Historical aspects are well and comprehensively covered, and the Anglo-American literature is given full consideration. The biochemistry of the blood and bile pigments, as well as the pathogenesis of jaundice, are discussed. As related to the problem of jaundice, the histopathology of the liver, the hepatic function tests, the physiology of the biliary tract and animal experimental studies, as well as clinical and therapeutic applications, are presented. The significant original work of the author, previously published, forms the starting point of most of the considerations or conclusions. He emphasizes the difference between stercobilinogen and urobilinogen. The former is considered the result of transformation of bilirubin by intestinal bacteria in the colon where it is in part absorbed
Physiologie und Pathologie des Bilirubinstoff-wechsels als Grundlagen der Ikterusforschung. JAMA. 1951;145(13):1022. doi:10.1001/jama.1951.02920310078044
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