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May 26, 1951


Author Affiliations

Charleston, W. Va.

From Kanawha Valley Hospital, Charleston, W. Va.

JAMA. 1951;146(4):335-337. doi:10.1001/jama.1951.63670040002007a

Since Thomas Hodgkin1 in 1832 first described seven cases of common lymph node and spleen enlargement and cachexia terminating fatally, a voluminous literature about the nature and etiology of this disease has accumulated. The most recent and complete review of this subject is that of Hoster and Dratman.2 Acute cases of Hodgkin's disease are rare. Cunningham3 found three cases; one was of six weeks' duration. Sternberg4 collected a number from the literature in which the duration was from eight days to several weeks. Harrell5 cited a case that was characterized by much pus formation and necrosis with very little fibrosis.

Gilbert6 analyzed the clinical course of 77 patients and made the following classification of cases: (1) those with an average rate of development (60 per cent), (2) those of slow evolution (20 per cent), (3) a rapid form in which death results within months