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To the Editor:
—Cortisone and pituitary adrenocorticotropic hormone (ACTH) have been shown to inhibit a wide variety of tissue reactions. An important application of this action on laryngeal edema due to a variety of causes is indicated in the following brief account. A detailed study of the cases mentioned below and others will be submitted at a later date.At first, an attempt was made to evaluate the action of cortisone on laryngeal edema secondary to a course of protracted fractional irradiation for carcinoma of the larynx. The result was most striking in that within 11 hours the edema had noticeably diminished and within four days the edema was minimal. No antibiotic or chemotherapeutic agents had been given. A second patient with laryngeal edema of similar pathogenesis was so treated. The results were equally impressive.Four patients with subglottic edema (croup), ranging from moderately severe to severe, were given cortisone.
Freeman J. CORTISONE AND LARYNGEAL EDEMA. JAMA. 1951;146(4):396. doi:10.1001/jama.1951.03670040096030
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