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June 2, 1951


JAMA. 1951;146(5):493. doi:10.1001/jama.1951.03670050075022

Cortisone and Gestation.  —Several years ago, Prof. Robert Courrier, general secretary to the Academy of Sciences, studied the influence of desoxycorticosterone on the gestation of rabbits. He found that this substance can replace the corpus luteum hormone; it allows the evolution of pregnancy in the castrated pregnant animal. Recently, in collaboration with Mme. Andrée Collonge, Professor Courrier studied the effect of cortisone on gestation. Rabbits were given daily injections of 25 mg. of cortisone acetate, dissolved in 1 cc. of an excipient, during four to seven days, between the 10th and the 23d days of gestation. This experiment gave the following results: Some rabbits aborted; with separation of the placenta; in others a hemorrhage occurred. When injections were given between the 10th and 14th days of pregnancy, autopsy revealed, besides living fetuses, evidences of resorbed ones; fetuses were diminished in size, from 24 to 20 mm., and placentas were pale.

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