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June 23, 1951

PERIODIC ARTHRALGIA IN TWENTY-THREE MEMBERS OF FIVE GENERATIONS OF A FAMILY

Author Affiliations

Philadelphia

From the Jefferson Medical College and Hospital.

JAMA. 1951;146(8):713-716. doi:10.1001/jama.1951.03670080021006
Abstract

A disorder characterized by pain in the joints at regularly recurrent short intervals over many years with no other disturbances and without permanent disability has been recognized as an entity for over a century. Several reviews of the subject have been made.1 It has been called hydrops genus intermittens, hydrops articulorum intermittens and intermittent hydrarthrosis. More recently the name periodic arthralgia has been used, because effusion into the joints is not always present and the disorder seems to be one member of a group of periodic disturbances. They are characterized respectively by regular recurrences of fever, abdominalgia, arthralgia, neutropenia, purpura and edema.2

More than 100 reports of cases of periodic arthralgia have been published, mostly in European journals. It is certain, however, that many more instances occur but are not discovered. Victims of the mildest form may never seek medical advice, or, because of its characteristic long duration,

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