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June 23, 1951

USE OF TETANUS SPORES FOR TESTING ANTISEPTICS IN VIVO

Author Affiliations

Baltimore

From the Biological Research Laboratories, Hynson, Westcott & Dunning, Inc.

JAMA. 1951;146(8):729-730. doi:10.1001/jama.1951.63670080003010
Abstract

In a report of Jan. 3, 1948,1 the Council on Pharmacy and Chemistry of the American Medical Association suggested that the "field of usefulness of organic mercurials should be explored, proved and defined. The proponents of these preparations should proceed seriously and diligently to this task." In following this suggestion of the Council we have developed a method which simulates conditions of use instead of employing test-tube experiments. We believe that this method encompasses the features required of a feasible antiseptic test, since the experiment takes place entirely in the animal body. Because death serves as the end point, it is unnecessary to read questionable clinical results or interpolate measurements.

Past studies have been criticized on the ground that streptococci and pneumococci change in virulence. Reported differences in antiseptic activity may be traced to insufficient mouse passage. Also, in the case of streptococci, pneumococci and anthrax, death in the

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