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July 21, 1951


Author Affiliations

St. Louis

From the Department of Surgery, Washington University School of Medicine.

JAMA. 1951;146(12):1091-1096. doi:10.1001/jama.1951.03670120001001

Since one of the chief objectives in the treatment of compound fractures is to prevent or combat infection in the wound, and since the introduction of antibiotics has profoundly influenced treatment of infections in general and of the pyogenic infections in particular, it seems in order to review the treatment of compound fractures in the light of the present day knowledge of antibiotics and the facility with which these potent agents can be used. In connection with some other work, I recently sent a questionnaire to a group of 24 orthopedic surgeons, in which I inquired about their use of antibiotics and other measures in the treatment of compound fractures. I found that there are wide differences of opinion concerning the dosage of antibiotics as well as minor differences on other phases of the treatment of these injuries.

Since compound fractures are among the most frequent and important injuries that