The clinical course of psoriasis has been recognized and described since the time of Celsus, but the cause of the disease still remains unknown. Psoriasis has been attributed to faulty metabolism of both proteins and fats, to parasitic and bacterial infections, to neurogenic disorders, to vitamin deficiency, and to dysfunction of the endocrine glands. A relationship with the arthritides has long been suspected. All these factors seemingly are unrelated, and treatments directed against them have given variable results. There has been no one drug or individual method of treatment that will cure psoriasis or even afford control of the disease in all cases with any degree of certainty. Because of the frequency with which the disease is encountered and the large problem that it presents, the announcement of a new remedy for psoriasis always arouses interest, and so Perlman's1 first report on the peroral use of undecylenic acid for
Rattner H, Rodin H. TREATMENT OF PSORIASIS WITH UNDECYLENIC ACID BY MOUTH. JAMA. 1951;146(12):1113–1115. doi:10.1001/jama.1951.03670120023006
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