This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor:
—In two editorials in the April 21 issue of The Journal of the American Medical Association, emphasis is directed to the emergence of penicillin-resistant bacterial strains, inferentially warning the medical world that ominous clinical problems may develop. In the Archives of Surgery, April, 1945, in a paper on "Topical Use of Concentrated Penicillin in Surface-Active Solution," and in The Journal of March 30, 1946, in another one on "Nonoperative Treatment of Osteomyelitis with Penicillin," a technique of multiple chemotherapy was described, with the use of an antibiotic (penicillin) and a detergent (aerosol OT), in which factors involved in the development of resistant strains were detailed, with attention directed to methods of controlling this problem.It is urged that all physicians using antibiotics return promptly to the basic principle of microbiology controlling this phennomenon of resistance. That clinically better results may follow the wisdom of such fundamental therapy
Grace EJ. RESISTANCE TO PENICILLIN. JAMA. 1951;146(12):1151. doi:10.1001/jama.1951.03670120061027
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: