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July 21, 1951


Author Affiliations

121 Fort Greene Pl., Brooklyn 17.

JAMA. 1951;146(12):1151. doi:10.1001/jama.1951.03670120061027

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To the Editor:  —In two editorials in the April 21 issue of The Journal of the American Medical Association, emphasis is directed to the emergence of penicillin-resistant bacterial strains, inferentially warning the medical world that ominous clinical problems may develop. In the Archives of Surgery, April, 1945, in a paper on "Topical Use of Concentrated Penicillin in Surface-Active Solution," and in The Journal of March 30, 1946, in another one on "Nonoperative Treatment of Osteomyelitis with Penicillin," a technique of multiple chemotherapy was described, with the use of an antibiotic (penicillin) and a detergent (aerosol OT), in which factors involved in the development of resistant strains were detailed, with attention directed to methods of controlling this problem.It is urged that all physicians using antibiotics return promptly to the basic principle of microbiology controlling this phennomenon of resistance. That clinically better results may follow the wisdom of such fundamental therapy

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