In an attempt to solve some of the problems of coronary heart disease in young men and women, thereby gaining a better understanding of the disease as it occurs in older patients, a special project was established at the Massachusetts General Hospital, Boston, in 1946. Since then, 100 patients who had myocardial infarction prior to the age of 40 have been studied. In addition, 146 persons (average age 38), healthy at the time of the examination, were studied for purposes of comparison. This report is confined to the clinical aspects of coronary heart disease in the former group.
For many years it has been recognized that atherosclerotic changes in the coronary arteries are not concomitant with "old age" alone, and that such changes can be, and often are, found in young men and women in whom none of the other expected changes of old age can be demonstrated. Indeed, case
Gertler MM, Driskell MM, Bland EF, et al. CLINICAL ASPECTS OF CORONARY HEART DISEASE: AN ANALYSIS OF 100 CASES IN PATIENTS 23 TO 40 YEARS OF AGE WITH MYOCARDIAL INFARCTION. JAMA. 1951;146(14):1291–1295. doi:10.1001/jama.1951.03670140017005
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