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August 18, 1951


JAMA. 1951;146(16):1525. doi:10.1001/jama.1951.03670160067024

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Macrocytic Anemias.  —During the last five years, the Hospital de Enfermedades de la Nutrición undertook the study and classification of macrocytic anemias, according to the observations made in patients from regions corresponding to the Mexican plateau (altitudes ranging between 1,600 and 2,200 meters above sea level). It was learned previously, in the same institution, that the mean corpuscular volume in normal subjects living in those areas is 80 to 105 cubic microns, which is 10 cubic microns more than values in the United States. This phenomenon was called physiological macrocytosis of the altitudes, as differentiated from the physiological polycythemia of altitudes, rarely found in Mexico.The results obtained emphasize several facts:

  1. Not a single case of pernicious anemia was found in Mexican patients, regardless of the length of the period of observation and despite the hospital's being an institution in which there is some concentration of hematological cases. Of

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