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August 25, 1951

TOXIC REACTIONS TO MERALLURIDE INJECTION (MERCUHYDRIN® SODIUM SOLUTION)

Author Affiliations

Topeka, Kan.

Resident in Internal Medicine, Medical Service, Winter Veterans Administration Hospital.

JAMA. 1951;146(17):1594-1595. doi:10.1001/jama.1951.63670170003011b
Abstract

A wide variety of toxic reactions following the use of mercurial diuretics has been reported. Although most of these reactions have been of a mild nature and have occurred infrequently in relation to the widespread use of mercurial diuretics, a number of fatal reactions are now well documented. With the introduction of locally less irritating preparations, the intramuscular route of administration has proved to be less toxic. Meralluride injection (mercuhydrin® sodium solution) is one such preparation in wide clinical use. Reports of nine cases of untoward reactions to meralluride injection were found in the literature. These included one case of acute dehydration,1 three fatal cases of toxic nephrosis,2 and five cases with reactions of an allergic nature.3

The following case is reported as another instance of severe hypersensitivity to meralluride injection, with subsequent successful use of mercaptomerin (thiomerin®) sodium.

REPORT OF A CASE  A 53 year old

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