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September 1, 1951

INACCURACY OF FOUR CHEMICAL PROCEDURES AS DIAGNOSTIC TESTS FOR CANCER

Author Affiliations

Beverly Hills, Calif.; Los Angeles

From the Bio-Science Laboratories (Dr. Henry and Dr. Berkman), and the Department of Biochemistry, University of Southern California School of Medicine (Mr. Little and Dr. Winzler).

JAMA. 1951;147(1):37-39. doi:10.1001/jama.1951.03670180043009
Abstract

During the past several years, interest in the chemical serodiagnosis of cancer has been revived by the introduction of several new procedures. Among these have been the methylene blue reduction time,1 the heat turbidity index,2 the Huggins iodoacetic acid index,3 and the level of the mucoprotein fraction in blood.4 Although none of the originators of these tests claimed them to be specific for the diagnosis of malignant disease, the suggestion has been made that some of these tests would be a definite aid in cancer diagnosis. The early evaluations of some of these tests indicated that they were fairly accurate. More recent studies on two of these procedures, however, have been rather discouraging.5 It has been suggested that a battery of tests might prove to be more accurate than any one of its component parts. It has been the purpose of this study to compare

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